Typical vaccine reactions may range from immediately after vaccination to days, months, or even years later. Other less common but more serious side effects can occur within minutes to hours after vaccination. Regular vet (Best Vet in The Universe) saw her Monday and her first thought was vaccine reaction. It is not uncommon at all that kittens/cats are lethargic and lose their appetite after vaccinations. However, it is common for many pets to experience mild side effects following vaccination, similar to those that humans experience. This is because the animal's immune system is fighting a low dose of the disease in the vaccine, which can upset the gastrointestinal tract. they took her to a veterinarian after seeing green mucus from her nose. Some cats also display signs of reduced physical activity, irritation on or by the vaccine location, slight fever, swelling, diarrhea, throwing up, exhaustion and difficulty walking. she was getting lethargic and not herself. The distemper vaccine causes many animals to feel sick to their stomach. This type of reaction occurs to some degree almost every time a cat gets vaccinated. every year after she got her booster shots she was very lethargic for a couple of days afterwards, it was almost like she had the flu. Organ Damage: A protein in the rabies vaccine can sometimes damage a cat's liver, kidneys and nervous system. my parents have a cat. The cause of your cat lethargy can be as simple and benign as plain old boredom, however, such listlessness could also signal disease, and it is in every cat owners interest to know the signs. the vet wouldn’t treat her without a rabies vaccine and determined she had a bad sinus infection. Organ damage can develop up to 45 days after a cat receives the vaccine. I have noticed, if you keep the cats stomach "full" after vaccines that seems to lessen the physical side effects. two days later she had some violent spasming while meowing very loudly. It is normal for a cat to be lethargic for up to seventy two hours, after vaccines. A 1 year booster vaccination is required after primary vaccination, followed by a vaccination every three years.” If a kitten is in a high risk situation (e.g., feral kitten that is to be released following a TNR [trap, neuter, return] protocol, or is living outside for any other reason), they can … Symptoms occasionally seen in the first 24 hours of vaccination include fever, tenderness, facial swelling, hives, swollen lymph nodes, vomiting, diarrhea, and rarely, acute liver and kidney failure. My cat was the same. Watch out for loss of motor skills, seizures and tissue damage at the vaccination site. Mild vomiting due to nausea is not uncommon, but … This is similar to human babies who often are cranky, lethargic, and even feverish after vaccines. In the days immediately following your fluffball's vaccination, closely monitor her for any unusual health symptoms. 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